Crystal Structure of DOT1L in complex with EPZ004777
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Crystal Structure of DOT1L in complex with EPZ004777 Descriptor: 7-{5-[(3-{[(4-tert-butylphenyl)carbamoyl]amino}propyl)(propan-2-yl)amino]-5-deoxy-beta-D-ribofuranosyl}-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Histone-lysine N-methyltransferase, H3 lysine-79 specific, ... Authors: Jin, L. Deposit date: 2012-04-09 Release date: 2012-10-17 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.85 Å) Cite: Conformational adaptation drives potent, selective and durable inhibition of the human protein methyltransferase DOT1L. Chem.Biol.Drug Des., 80, 2012
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2012-04-09
