Nucleosome intermediate preference of SMARCAD1 chromatin remodeler, and the structural insights. Nucleosome intermediate preference of SMARCAD1 chromatin remodeler, and the structural insights

Examination of the repositioning of nucleosome and hexasome-sized particles induced by the SMARCAD1 family proteins in cells support the hexasome-binding mode. Our findings reveal a new mode of chromatin regulation, wherein the nucleosome intermediates are specially remodeled through an ATP-dependent process. Overall design: MNase-seq in Saccharomyces cerevisiae. Compare nucleosome shift between WT-mutant(dFun30). Two biological replicates were sampled.