Transcriptomic profiling of human senescent cells in the setting of grape seed extract intervention. Transcriptomic profiling of human senescent cells in the setting of grape seed extract intervention

Aging and age-related pathologies can be delayed by specifically targeting the senescence-associated secretory phenotype (SASP), a hallmark feature of senescent cells. Achieving the goal using small molecule inhibitors would have a tremendous impact on the quality of lifespan and burden of age-related chronic diseases. We report the potential of grape seed extract (GSE), a naturally existing source of phytochemicals including terpenoids, carotenoids, and flavonoids, in targeting senescent cells via induction of programmed cell death. This study demonstrates the impact of GSE as a medicinal compound on the expression profile of senescent cells and provides a strong rationale for its future use in geriatric medicine. Overall design: Examination of in vitro efficacy of GSE, a grape-derived product that has been used to maintain healthy condition through controlling inflammatory responses by decreasing the expression of inflammation-related factors, in modulating the expression profile of senescent cells and their survival.