Mus Musculus Brain FMR1KO, FMR1WT small RNA seq. Mus Musculus Brain FMR1KO, FMR1WT small RNA seq

NIAID Data Ecosystem2026-05-01 收录

发育疾病分子机制

smallRNA测序分析

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA980134 数据链接链接失效反馈

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Mus Musculus Brain FMR1KO, FMR1WT small RNA seq Overall design: siblings

创建时间：

2023-06-05

Sotos Syndrome Is Associated with Deregulation of the MAPK/ERK-Signaling Pathway

MAPK信号通路调控

发育疾病分子机制

Sotos syndrome (SoS) is characterized by tall stature, characteristic craniofacial features and mental retardation. It is caused by haploinsufficiency of the NSD1 gene. In this study, our objective wa

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The RNA-binding protein Sfpq regulates long neuronal genes in transcriptional elongation [RNA-seq]. Mus musculus

神经元转录调控

发育疾病分子机制

Mammalian neurons express extra-long pre-mRNAs which are vulnerable to misregualtion of transcriptional elongation or processing but their regulation is still largely unknown. Here we found that RNA-b

NIAID Data Ecosystem70

MeCP2 Represses the Activity of Topoisomerase IIb in Long Neuronal Genes [ChIP-Seq]

发育疾病分子机制

基因转录调控

A unique signature of neuronal transcriptomes is the high expression of the longest genes in the genome (e.g. >100 kilobases). These genes encode proteins with essential functions in neuronal physiolo

NIAID Data Ecosystem20

Additional file 4: of RNA sequencing and proteomics approaches reveal novel deficits in the cortex of Mecp2-deficient mice, a model for Rett syndrome

发育疾病分子机制

CNS细胞类型特异性组学

CNS cell type-specific genes from Zhang et al.’s study compared to the Sharma et al. study. Significant DE genes (DEG) identified as cell type-specific from the Zhang et al. study [69] were compared t

Figshare2017-10-25 更新70

Developmental dynamics of the postsynaptic proteome to understand synaptic maturation and dysmaturation

突触蛋白质组学

发育疾病分子机制

The postsynaptic density (PSD) is a protein condensate composed of ~1,000 proteins beneath the postsynaptic membrane of excitatory synapses. The number, shape, and plasticity of synapses are altered d

NIAID Data Ecosystem50

Mus Musculus Brain FMR1KO, FMR1WT small RNA seq. Mus Musculus Brain FMR1KO, FMR1WT small RNA seq

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