Data set presented in Nienaltowski et al. "Fractional response analysis reveals logarithmic cytokine responses in cellular populations", Nature Communication, in press.

The data set, as presented in the paper, contains four components, which are available in distinct files:

(i) data.fra.cytof.all_cell_types.rds containing IFN-α2α responses in terms of whole-cell tyrosine phosphorylation levels of effector proteins STAT1, STAT3, STAT4, STAT5, and STAT6 measured jointly in human peripheral blood mononuclear cells using mass cytometry;

(ii) data.fra.ps1.rds containing IFN-γ responses in terms of nuclear phosphorylated STAT1 measured in human monocyte cell line U937, differentiated into macrophage-like cells, measured with immunostaining and microscopy imaging;

(iii) data.fra.ps3.rds containing IL-10 responses in terms of nuclear phosphorylated STAT3 measured in human monocyte cell line U937, differentiated into macrophage-like cells, measured with immunostaining and microscopy imaging;

(iv) data.fra.nfkb.all.rds containing TNF-α responses in terms of nuclear translocation of NF-κB complex measured in murine embryonic fibroblast cell line using live confocal imaging.