Additional file 2 of Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation

Additional file 2: Supplemental dataset S2. Differentially abundance values of proteins comparing four groups (HC, LTBI, NTM and active TB) to each other’s measured from analyzed in two technical replicates computing the abundances with the MaxLFQ software tool. The analytes were measured from 40 enrolled participants (10 each for the cohorts HC, LTBI, active TB and NTM) from unstimulated and 40 enrolled participants (10 each for the cohorts HC, LTBI, active TB and NTM) from stimulated. Thirty-five proteins were differentially expressed in LTBI comparing to HC, 43 proteins were differentially expressed in NTM comparing to HC and 49 proteins were differentially expressed in active TB comparing to HC, 34 proteins were differentially expressed in NTM as compared to LTBI, 41 proteins were differentially expressed in active TB as compared to LTBI, and 39 proteins were differentially expressed in active TB as compared to NTM in unstimulated plasma samples. In the meanwhile, 50 proteins were differential expressed in LTBI comparing to HC, 41 proteins were differential expressed in NTM comparing to HC, 61 were differentially expressed in active TB comparing to HC, 13 proteins were differentially expressed in NTM as compared to LTBI, 64 proteins were differentially expressed in active TB as compared to LTBI, and 43 proteins were differentially expressed in active TB as compared to NTM. Independent-sample t testing was performed and P-values < 0.05 were considered statistically significant. Student’s t-test difference of + 1 or − 1 was used as cutoff value. False discovery rate was calculated and q-values ≤0.05 were also considered statistically significant. Columns in the Excel files designate technical replicates (donated by rep), comparison groups, peptides, T-test difference, t-test values, q-values, protein ID, protein names and gene names. Significantly up-regulated proteins were highlighted by red color, significantly down-regulated proteins were highlighted by blue color, non-significantly up and down regulated proteins were highlighted by yellow color and not regulated proteins were highlighted by black color.