Global transcriptomic profiling of the bone marrow stromal microenvironment during postnatal development, aging, and inflammation

RNA-sequencing of a longitudinal comparison of four principal mesenchymal and endothelial stromal cell types (CXCL12-abundant reticular cells, PDGFR-a+ Sca-1+, sinusoidal and arterial endothelial cells), isolated from early postnatal, adult and aged mice. Additional transcriptional profiling of the response of CXCL12-abundant reticular cells and sinusoidal endothelial cells to infection-mimicking agents. Overall design: RNA-sequencing of four FACS-isolated mouse bone marrow stromal cells at different age stages and conditions.