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AMPK signaling for naïve pluripotency [Hs]

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NIAID Data Ecosystem2026-04-30 收录
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We show activation of AMP kinase (AMPK) with single chemical compounds can endow naïve pluripotency. AMPK activators reverted early-stage differentiating cells or epi-stem cells to naïve state. Moreover, AMPK activators reverted human ESCs to naïve state with pluripotent gene expression profiles and X-chromosome reactivation. Overall design: We analyzed gene expression profiles of human ESCs with AICAR during differentiation and reversion

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2023-01-11
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