Bulk-RNA-seq of T-bet KO and Wildtype microglia

NIAID Data Ecosystem2026-05-02 收录

胶质细胞转录组学

T-bet基因功能研究

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP488541 数据链接链接失效反馈

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Bulk-RNA-seq of FACS isolated microglia from steady-state adult (10-week-old) T-bet KO and wildtype mice raised in a SPF facility. The mice have a C57BL/6 background.

创建时间：

2025-06-01

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胶质细胞转录组学

Alzheimer's disease (AD) is the most prevalent form of dementia and is characterized by abnormal extracellular aggregates of amyloid-b and intraneuronal hyperphosphorylated, tau tangles and neuropil t

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TREM2 Gene Dosage Increase Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer’s Disease Models

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TREM2 BAC transgenic mice with elevated expression of human TREM2 in microglia under its endogenous regulation without overexpression of other TREM-like genes on the BAC were generated and crossed wit

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IL-1β driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia

阿尔茨海默病免疫调节

胶质细胞转录组学

Neuroinflammation is thought to contribute to the pathogenesis of Alzheimer’s disease (AD), yet numerous studies have demonstrated a beneficial role for neuroinflammation in amyloid plaque clearance.

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Additional file 2 of Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

TDP43蛋白病

胶质细胞转录组学

Additional file 2. Comparison of principal component scores between male and female rNLS8 control mice.

Figshare2024-02-20 更新70

Next generation sequencing revealed disease-specific microglia classes relying on distinct transcriptomes. Next generation sequencing revealed disease-specific microglia classes relying on distinct transcriptomes

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胶质细胞转录组学

Microglia in the spinal dorsal horn have been implicated in the pathogenesis of neuropathic pain following peripheral nerve injury. We have revently found that CD11c-expressing spinal microglia appear

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Bulk-RNA-seq of T-bet KO and Wildtype microglia

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