Murine study of sepsis-induced cardiac gene expression changes in vivo

We systematically assessed the transcriptomic changes of heart biopsies of mice that had undergone polymicrobial sepsis. Data indicate strong cardiac in vivo responses during murine sepsis affecting a large amount of pathways and categories including cytokines, mitochondria, immune system and cardiomyocytes. RNA from murine heart muscle tissue (n=4 for sepsis, n=4 for controls) was extracted and subjected to microarray analysis for comparison of transcriptomic responses.