Table_2_Dysfunctional Interaction Between the Dorsal Attention Network and the Default Mode Network in Patients With Type 2 Diabetes Mellitus.DOCX

The risk of cognitive impairment in patients with type 2 diabetes mellitus (T2DM) is significantly higher than that in the general population, but the exact neurophysiological mechanism underlying this is still unclear. An abnormal change in the intrinsic anticorrelation of the dorsal attention network (DAN) and the default mode network (DMN) is thought to be the mechanism underlying cognitive deficits that occur in many psychiatric disorders, but this association has rarely been tested in T2DM. This study explored the relationship between the interaction patterns of the DAN-DMN and clinical/cognitive variables in patients with T2DM. Forty-four patients with T2DM and 47 sex-, age-, and education-matched healthy controls (HCs) underwent neuropsychological assessments, independent component analysis (ICA), and functional network connection analysis (FNC). The relationship of DAN-DMN anticorrelation with the results of a battery of neuropsychological tests was also assessed. Relative to the HC group, the DMN showed decreased functional connectivity (FC) in the right precuneus, and the DAN showed decreased FC in the left inferior parietal lobule (IPL) in patients with T2DM. Subsequent FNC analysis revealed that, compared with the HC group, the T2DM patients displayed significantly increased inter-network connectivity between the DAN and DMN. These abnormal changes were correlated with the scores of multiple neuropsychological assessments (P < 0.05). These findings indicate abnormal changes in the interaction patterns of the DAN-DMN may be involved in the neuropathology of attention and general cognitive dysfunction in T2DM patients.

2型糖尿病（T2DM）患者认知障碍的风险显著高于普通人群，但其背后的神经生理机制尚不明确。背侧注意力网络（DAN）与默认模式网络（DMN）内在抗相关性的异常变化被认为是多发性精神障碍中出现的认知缺陷的机制，但这种关联在T2DM中很少被检验。本研究探讨了DAN-DMN相互作用模式与T2DM患者临床/认知变量之间的关系。44名T2DM患者和47名性别、年龄和教育程度相匹配的健康对照者（HCs）接受了神经心理学评估、独立成分分析（ICA）和功能性网络连接分析（FNC）。还评估了DAN-DMN抗相关性与一系列神经心理学测试结果的关系。与HC组相比，T2DM患者的DMN在右侧顶叶皮层的功能连接（FC）降低，DAN在左侧颞下叶（IPL）的功能连接降低。后续的FNC分析显示，与HC组相比，T2DM患者的DAN和DMN之间的网络连接性显著增加。这些异常变化与多项神经心理学评估的得分相关（P < 0.05）。这些发现表明，DAN-DMN相互作用模式的异常变化可能涉及T2DM患者注意力和一般认知功能障碍的神经病理学过程。