DNA methylation profile of PBMC following decitabine therapy
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE80377
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资源简介：
The epigenetic regulation, for example, DNA methylation, controls the development and differentiation of both tumor cells and immunocytes. Treatment with DNA demethylating agent (such as decitabine) has shown a dramatic clinical benefit in hematological malignancies and solid tumors. However, the influence of epigenetic therapy on host immune system remains unclear. To investigate the effects of low-dose decitabine therapy on T cells, we collected whole blood samples from two solid tumor patients pre and post low-dose decitabine therapy, and detected the DNA methylation profiles of PBMCs.
创建时间：
2019-03-22
