Pd-Catalyzed Asymmetric Dearomative Arylation of Indoles via a Desymmetrization Strategy
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https://figshare.com/articles/dataset/Pd-Catalyzed_Asymmetric_Dearomative_Arylation_of_Indoles_via_a_Desymmetrization_Strategy/19169522
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资源简介：
Pd-catalyzed asymmetric dearomative
arylation of C3-substituted
indoles is realized via a desymmetrization strategy. A BINOL-derived
chiral phosphoramidite ligand is found to be highly efficient for
the stereoselective control in this reaction. This method provides
a convenient synthesis of spiroindolenines bearing two stereogenic
centers in good yields (up to 98%) with excellent diastereo- and enantioselectivities
(up to >20:1 dr and 97% ee), which could also be applied in asymmetric
dearomative arylation of the simple C3-tethered indoles.
创建时间：
2022-02-14
