Enrichment by protein function of ANOVA-identified genes.

Over representation analysis of the 403 ANOVA interaction-identified genes was performed based on broadly defined protein functions. The Metacore database for the human genome annotates 23,844 network objects for the background list. Column abbreviations: Actual, number of ANOVA identified objects for a given class; R, number of background objects for a given class; Expected, mean value for hypergeometric distribution (403*R/23,844); Ratio, the ratio of actual/expected; p-value, probability to have the given actual value or higher (or lower for negative z-score); In data set, percent of objects of a given function in the ANOVA dataset; In protein function, percent of ANOVA objects of a given function relative to the number of background objects with the same function; Protein function in database, percentage of ANOVA objects of a given function in the background list.