Protein arginine methyltransferase 5 (PRMT5) over-expression in hematological and solid tumors methylates arginine residues on cellular proteins involved in important cancer functions including cell c
PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto
Concentration-dependent inhibition of endothelial-network formation by the vascular inhibitors Vatalanib (PTK787), Semaxinib (SU5416)sFlt-1, anti-VEGF, Prinomastat hydrochloride andSutent, measured as
