CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455
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CRYSTAL STRUCTURE OF PXR IN COMPLEX WITH XPC-7455 Descriptor: 4-[[(1~{S})-1-[2,5-bis(fluoranyl)phenyl]ethyl]amino]-5-chloranyl-2-fluoranyl-~{N}-(1,3-thiazol-4-yl)benzenesulfonamide, Nuclear receptor subfamily 1 group I member 2 Authors: Focken, T, Maskos, K, Griessner, A, Krapp, S. Deposit date: 2019-06-26 Release date: 2019-10-02 Last modified: 2024-05-15 Method: X-RAY DIFFRACTION (2.7 Å) Cite: Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy. J.Med.Chem., 62, 2019
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2019-06-26
