Glucose-6-phosphate dehydrogenase deficiency and stroke outcomes

Objective: To ascertain whether G6PD deficiency affects outcomes at 3 months after stroke, we recruited 1251 patients with acute ischemic stroke and detected erythrocyte-G6PD activity.

Methods: The prospective study participants consisted of 1,251 patients with ischemic stroke within 2 weeks of onset from four clinical centers in South China. Patients were individually categorized into the G6PD-deficiency group and non-G6PD-deficiency group according to erythrocyte-G6PD activity upon admission. Baseline characteristics and clinical outcomes (modified Rankin Scale score [mRS], poor functional outcome [mRS ≥ 2] at 3 months, and death) were compared between the two groups. The associations of G6PD deficiency with outcomes were evaluated using Cox proportional hazards and logistic regression analyses.

Results: Among 1251 patients, 150 (12.0 %) were G6PD deficient; patients with G6PD deficiency had higher proportions of large-artery atherosclerosis (56.7% vs. 46.0% in non-G6PD-deficien...