Effect of telmisartan, irbesartan, fluvastatin and doxycycline on aortic diameters of Ang II-infused ApoE^−/− mice.

Noninvasive transabdominal ultrasonography was used to measure suprarenal aortic diameters in individual mice prior to drug treatment (day -7), on the Ang II infusion day (day 0), and 3, 7, 14, 21 and 28 days after Ang II infusion. Data are given as mean ± standard derivation of the aortic diameters for all groups, with all dimensions listed in units of mm. Number of mice in each group is shown in the parenthesis. Two-way ANOVA analysis followed by Newman-Keuls post-test, *P<0.05 and **P<0.01 compared to the control group at same measurement day.