DYSADAPTATION MECHANISMS OF THE HUMAN'S IN ANTARCTIC

It is for the first time fullfilled the genetic typization of the participants of Antarctic expedition on the presence of an allele polymorphism of specific genetic factor (hypoxia inducted factor - HIF-1?). The significance of such human gene HIF-1? polymorphism is studied in correction to development of adaptative-dysadaptative rebuildings of the functional systems at a continuous stay in Antarctic. It is shown the stabile reduction of regulation mechanisms of an organism oxygen modes under influence ofAntarctic factors and hypoxia loading among winterers with Ñ/Ò polymorphism of the gene HIF-1?, that has prognostic importance and opens way to deepened study of the molecular mechanisms role in development adaptative-dysadaptativeprocesses in ahuman in extreme conditions. ​