Development of complete retinal pigment epithelium and outer retina (cRORA) atrophy over time.

Only the 125 eyes without any sign of cRORA at the commencement of anti-VEGF treatment were included in this subset. Over time, a significant increase in the number of eyes that exhibit cRORA can be observed and all eyes with follow-up of more than 10 years show cRORA by the end of the study. cRORA size increases over time, although yearly increases vary between 0.4 and 1.7 mm2 with a mean of 1.22 mm2 per year.