A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes

A new copper-promoted three-component method for constructing ketoximes has been developed. This transformation can be achieved using indoles/pyrroles with the in situ generated 2,2,2-trifluoro­diazo­ethane and nitrite species under mild conditions, thus offering a direct pathway to (E)-3-indolyl/2-pyrrolyl trifluoro­methyl­ketoximes.