A Direct Copper-Promoted Three-Component Entry to Trifluoromethylketoximes
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A new copper-promoted three-component method for constructing ketoximes has been developed. This transformation can be achieved using indoles/pyrroles with the in situ generated 2,2,2-trifluorodiazoethane and nitrite species under mild conditions, thus offering a direct pathway to (E)-3-indolyl/2-pyrrolyl trifluoromethylketoximes.
创建时间:
2016-02-17



