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Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP

NIAID Data Ecosystem2026-05-01 收录

抗疟药物靶点

酶-抑制剂复合物解析

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Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP

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创建时间：

2023-08-30

疟原虫酶结构

抗疟药物靶点

Crystal Structure of Plasmodium vivax geranylgeranylpyrophosphate synthase PVX_092040 with zoledronate and IPP bound Descriptor: 1,2-ETHANEDIOL, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Farnesyl py

Protein Data Bank Japan2023-12-27 更新90

Crystal structure of bromodomain from Plasmodium falciparum GCN5 complexed with a ligand

抗疟药物靶点

蛋白质-配体复合物结构

Crystal structure of bromodomain from Plasmodium falciparum GCN5 complexed with a ligand

NIAID Data Ecosystem60

Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester.

疟原虫酶结构解析

抗疟药物靶点

Plasmodium vivax N-myristoyltransferase in complex with YnC12-CoA thioester. Descriptor: CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ... Authors: Wright, M.H, Clough, B

Protein Data Bank Japan2024-05-08 更新20

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites

疟原虫顶质体蛋白质组学

抗疟药物靶点

Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote–eukaryote endosymbiosis, t

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Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery

抗疟药物靶点

进化基因组学靶标验证

Although many new anti-infectives have been discovered and developed solely using phenotypic cellular screening and assay optimization, most researchers recognize that structure-guided drug design is

NIAID Data Ecosystem40

Wild-type Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF01302, NADPH, and dUMP

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