Effect of baicalein on cisplatin-induced alterations in renal antioxidants.

All data were expressed as mean ± S.E.M, N = 6. Where, Control, vehicle (2% gum acacia) treated mice; Baicalein, baicalein (50mg/kg) alone treated mice; Cisplatin, cisplatin-induced mice; Cis+Bai-25, baicalein at a dose of 25 mg/kg body weight treated cisplatin-induced mice; Cis+Bai-50, baicalein at a dose of 50 mg/kg body weight treated cisplatin-induced mice; GSH, reduced glutathione (mg/g tissue); GR, glutathione reductase (U/mg protein); GST, glutathione S-transferase (nmol of CDNB conjugated/ min/ mg/ protein); SOD, superoxide dismutase (% of control); CAT, catalase (U/mg protein); NQO1, NAD(P)H: quinone oxidoreductase 1 (nmol of DCIP reduced/min/ mg/ protein); CDNB, 1-chloro-2, 4-dinitrobenzene; DCIP, 2, 6-dichlorophenolindophenol.
#p< 0.001 and †p< 0.01 vs Vehicle control,
*p< 0.05, **p< 0.01 and ***p< 0.001 vs Cisplatin control group.
Effect of baicalein on cisplatin-induced alterations in renal antioxidants.