Thioester Hydrolysis Promoted by a Mononuclear Zinc Complex
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https://figshare.com/articles/dataset/Thioester_Hydrolysis_Promoted_by_a_Mononuclear_Zinc_Complex/2796355
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资源简介：
The mononuclear zinc complex [(bpta)Zn](ClO4)2·0.5H2O promotes the hydrolysis of the thioester PhCH(OH)C(O)SCD3 when dissolved in CH3CN:H2O (50:50 buffered at pH 9.0). This reaction results in the formation of a mixture of CD3SH and a zinc thiolate complex, the latter of which can be protonated to generate additional CD3SH. Kinetic studies revealed an overall second-order reaction with an activation energy that is similar to that found for aqueous OH− promoted thioester hydrolysis. These studies represent the first investigation of chemistry relevant to that occurring in the monozinc-containing form of human glyoxalase II.
创建时间：
2016-02-25
