Raw Data for "Palladium-Catalyzed Monoarylation of Cyclopropylamine"

PROJECT DESCRIPTION:
We report a novel palladium-catalyzed protocol for the monoarylation
of cyclopropylamine using the sterically demanding and electron-rich
adamantyl-substituted YPhos ligand adYPhos. This method enables the
efficient coupling of a wide range of (hetero)aryl chlorides at room temperature.
The reported ligand enhances the scope for the application of YPhos ligands
in amination reactions to more challenging substrates. The protocol is versatile,
accommodating various functional groups and extending to larger cycloalkylamines,
all accessible under feasible and mild conditions.