Tumor-Stroma Dynamics in Gastric Cancer: Integrating Co-Culture Models and Transcriptomic Analysis for Tailored Therapy

Gastric cancer represents a significant global health challenge, characterized by limited treatment options and poor prognoses, largely due to its inherent heterogeneity among patients. Establishing a co-culture model integrating organoids with tumor-stroma cells, coupled with drug selection guided by organoids transcriptomic profile, underscores the significance of personalized therapy tailored to the unique molecular and functional characteristics of each patient's tumor.