Growth Cone Localization of the mRNA Encoding the Chromatin Regulator HMGN5 Modulates Neurite Outgrowth.

Data from ProteomeXchange, PXD ID: PXD001070. File: 130514_L_HH3_140514085016.mzml. Published as part of Mol Cell Biol. 2015 Mar 30 . From the Abstract: {{i}}... We report that the mRNA encoding the HMGN5 chromatin binding protein localizes to growth cones of both neuronal-like cells and of hippocampal neurons, where it has the potential to be translated, and that HMGN5 can be retrogradely transported into the nucleus along neurites. Loss of HMGN5 function induces transcriptional changes and impairs neurite outgrowth while HMGN5 overexpression induces neurite outgrowth and chromatin decompaction ... {{/i}}