Investigating the consequences of the mating system for drug resistance evolution in C. elegans

The rise of anthelmintic-resistant strains in livestock threatens both animal and human health. Understanding the factors influencing anthelmintic resistance is crucial to mitigate the threat posed by these parasites. Due to difficulties in studying parasitic worms in the laboratory, the non-parasitic nematode Caenorhabditis elegans is used as a model organism to investigate anthelmintic resistance evolution. However, the suitability of this free-living nematode as a model for parasitic worms is debatable due to its rare androdioecious reproductive system, raising questions about the generalizability of findings from evolutionary experiments in C. elegans to other species. In this study, we developed a polygenic, population genetic model combined with pharmacodynamic approaches to investigate the effects of reproductive strategy and other aspects, such as dominance, mutational effects, the number of loci, and population size, on determining the dynamics and outcome of evolutionary proce..., , # Investigating the consequences of the mating system for drug resistance evolution in C. elegans

Dataset DOI: [10.5061/dryad.fqz612k4h](10.5061/dryad.fqz612k4h)

## Description of the data and file structure

There are two main types of data, all described in detail below. 

1\) Python code used to generate all the data used in the article, ending .ipynb or .py. 

* DataMerger.py
* AnalyzeClusterData.ipynb
* MatingWormsCluster.ipynb
* PlottingClusterData.ipynb
* WormFunctionsMating.py
* FitnessFigures.ipynb
* ScanningXi.ipynb
* ShowExtinction.ipynb

2\) Simulated data in .npy format, readable by Python. 

* CombinedDataL2.zip (114.34 MB)
* CombinedDataL6.zip (876.47 MB)

## Code:

The Python code was written in Python 3 in Jupyter Notebook. 

Necessary packages: sys, numpy, matplotlib and WormFunctionsMating.py

### WormFunctionsMating.py

This is the main file containing all the classes (e.g. Experiment, Population) that are necessary to run the simulations. This file needs t...,