Study design.

aRestraint procedures consisted of removing the animal from their home cage, recording body weight, restraining for dose administration and then returning the animal to its home cage. Animals receiving gavage were administered water via oral gavage at a dose volume of 10 mL/kg.
bRestraint in Broome restrainers followed by 0.16 mL blood collected from the lateral tail vein into serum separator tubes at 1, 2, 4, 8 hours post dose on days 1 and 4 for Groups 2 and 3, respectively.