Transcriptome analyses for salt sensitivity of blood pressure. Transcriptome analyses for salt sensitivity of blood pressure

Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease. However, the pathogenic mechanisms of SSBP are still uncertain. Thus, ceRNA microarray was applied to identify differentially expressed lncRNAs and mRNAs. The whole blood samples from 10 hypertensives and 10 normotensives were collected by professional nurses in community health centers using EDTA blood tube. The samples were classified according to the salt sensitivity (SS, salt sensitivity; SR, salt resistant) and hypertension (H, hypertensives; N, normotensives). QRT-PCR and cell experiments would be also implemented to validate the reliability of the results. Overall design: In the ceRNA microarray, 10 salt-sensitive individuals were regarded as cases and 10 salt-resistant individuals were controls. The whole blood samples were collected by professional nurses in the morning after fasting for 8 hours. There were no interventions on participants before collecting the blood samples.