Dynamic upregulation of retinoic acid RA signal in the early postnatal murine heart promotes cardiomyocyte cell cycle exit and maturation

Retinoic acid (RA), the major active metabolite of vitamin A, is essential for organogenesis, homeostasis, and tissue morphogenesis. Despite the importance of RA signaling in embryo heart development, little is known about its function in the early postnatal period. To analyze the function of RA signaling during perinatal heart development, we investigated the mRNA expression levels of multiple retinoid metabolic genes at various perinatal stages using RNA-seq analysis. Comparative gene expression profiling analysis of RNA-seq data for each stage of ventricles from P3, P6, P12 and P24 mice.