Nonsense suppression as a mechanism of genetic complemtation in the opportunistic pathogen Mycobacterium marinum

Here, we report the discovery of a novel mechanism of genetic complementation in M. marinum. We found that nonsense suppression was causing genetic complementation. Nonsense suppression was linked to alterations in cell permeability and exposure to the aminoglycoside antibiotic, hygromycin. Examination of differences between wild-type, mutant and complemented strains of M. marinum.