de-stabilizing innate immunity in Covid-19: effects of its own positive feedback and erratic viremia on the alternative pathway of complement

Complement provides powerful, fast responses in the human circulation to SARS-CoV-2 (Covid-19 virus) infection of the lower respiratory tract. Covid-19 effects were investigated in a revised human in silico Mass Action model of Complement’s Alternative pathway (AP) responses. Bursts of newly circulating virions increased the fission of Complement protein C3 into C3a and C3b via stimulation of the lectin pathway or inhibited Complement factor H. Viral reproduction sub-models incorporated smoothly exponential or step-wise exponential growth. Starting complement protein concentrations were drawn randomly from published normal male or female ranges and each infection model run for 10 days. C3 and factor B (FB) syntheses driven by Lectin Pathway stimulation led to declining plasma C3 and increasing FB concentrations. The C3 convertase concentration, a driver of viral elimination, could match viral growth over three orders of magnitude but near-complete exhaustion of circulating C3 was more p..., The data was collected over a half century by many scientists and published in the available literature. It includes normal protein concentrations with their inter-individual variability (statistical distributions, where available). Also included are data on enzyme kinetics related to the processing of these proteins in health and disease., , # Data from: de-stabilizing innate immunity in Covid-19: effects of its own positive feedback and erratic viremia on the alternative pathway of complement

[https://doi.org/10.5061/dryad.jm63xsjhj](https://doi.org/10.5061/dryad.jm63xsjhj)

## Description of the data and file structure

Each jmp file (except the two stubs) contains data representing the evolution over 10 days of modelled alternative pathway protein concentrations in the the human extracellular fluid of one simulated male or female person, either in the healthy steady state or during stimulation via the simulated lectin pathway (or after reduction in simulated factor H concentration) provoked by SARS-Cov2 infection. The individual files are labelled as follows (see \"Description of Variables in JMP Spreadsheets.pdf\" file for definitions): PR = progressive (exponential growth of coronavirus); SW = Stepwise - mostly tenfold - \"instantaneous\" growth of coronavirus, per 2 days (along an exponential 10-fold per two day pathway)...