Sex-related differences in lactotroph tumor aggressiveness are associated with a specific gene-expression signature and genome instability

we aimed to explore the molecular importance of the estrogen pathway through a detailed analysis of the transcriptomic profile of lactotroph tumors from 20 men and 10 women. We undertook gene expression analysis of the 30 selected lactotroph tumors following their pathological grading using the five-tiered classification. Thirty frozen tumors stored at the Neurobiotec Bank (Lyon, France) were selected from a series of 89 lactotroph pituitary tumors we had previously used to report the existence of ERalpha-associated sex-related differences among men and women