Identifying Causes of Fracture Beyond Bone Mineral Density: Evidence from Human Genetics
收藏NIAID Data Ecosystem2026-03-13 收录
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https://figshare.com/articles/dataset/Identifying_Causes_of_Fracture_Beyond_Bone_Mineral_Density_Evidence_from_Human_Genetics/19749949
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Full Summary Statistics and Supplementary Tables
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Genomic structural equation models were built to investigate genetic effects on fracture that were mediated vs. not mediated by bone mineral density (BMD).
---------- Summary Statistics
Frax-eBMD-related.gwas.txt.gz: genetic effects mediated by estimated BMD
Frax-non-eBMD.gwas.txt.gz: genetic effects not mediated by estimated BMD
Frax-FNBMD-related.gwas.txt.gz: genetic effects mediated by femoral neck BMD
Frax-non-FNBMD.gwas.txt.gz: genetic effects not mediated by femoral neck BMD
Frax-LSBMD-related.gwas.txt.gz: genetic effects mediated by lumbar spine BMD
Frax-non-LSBMD.gwas.txt.gz: genetic effects not mediated by lumbar spine BMD
---------- Supplementary Tables
Table S3. List of COJO-independent SNPs with BMD-related effects on fracture risk.
Table S4. Statistical fine-mapping of loci conferring non-BMD effects.
Table S5. GWAS signals identified by PhenoScanner for each COJO-independent SNP.
Table S7. Parameter optimization for polygenic risk scores.
创建时间：
2022-06-05
