HDM2 in complex with a 3,3-Disubstituted Piperidine
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HDM2 in complex with a 3,3-Disubstituted Piperidine Descriptor: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, {4-[2-(2-hydroxyethoxy)phenyl]piperazin-1-yl}[(2R,3S)-2-propyl-1-{[4-(trifluoromethyl)pyridin-3-yl]carbonyl}-3-{[5-(trifluoromethyl)thiophen-3-yl]oxy}piperidin-3-yl]methanone Authors: Scapin, G. Deposit date: 2016-01-16 Release date: 2016-04-06 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (1.74 Å) Cite: Discovery of Novel 3,3-Disubstituted Piperidines as Orally Bioavailable, Potent, and Efficacious HDM2-p53 Inhibitors. Acs Med.Chem.Lett., 7, 2016
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2016-01-16
