HyperMap: An Efficient Meta-Learning Framework for Transferring Perturbation Responses Across Diverse Biological Contexts

HyperMapDB is a unified resource of predicted transcriptional responses to 19,036 genetic and chemical perturbations across 19 human cell lines. Predictions were generated using HyperMap, a meta-learning framework that transfers perturbation response knowledge from existing atlases to new biological contexts. The dataset contains predicted single-cell gene expression deltas for 2,500 genes.