Westlake N-of-1 Trials for Macronutrient Intake. human gut metagenome

The WE-MACNUTR was an integration of a serials of n-of-1 trials, which was conducted between October 20, 2019 and December 31, 2019. This study contained 3 cycles (with 3 cross-over) of whole feeding primarily aiming to investigate individual postprandial glycemic as well as gut microbial responses to high-carbohydrate low-fat (HC) and low-carbohydrate high-fat (LC) diets. The study consisted of three successive 12-day dietary intervention pairs including a 6-day washout period between each 6-day intervention. The diets were isocaloric with fat and carbohydrate contents as their primary distinguishing features. The HC diet consist of 65-75% total energy intake (E) from carbohydrate and LC diet consist of 15-25%E from carbohydrate. Protein provided 15% energy in all dietary interventions.