A Palladium-Catalyzed Carbonylation Approach to Acid Chloride Synthesis
收藏NIAID Data Ecosystem2026-03-08 收录
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https://figshare.com/articles/dataset/A_Palladium_Catalyzed_Carbonylation_Approach_to_Acid_Chloride_Synthesis/2354236
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资源简介：
We describe a new approach to acid
chloride synthesis via the palladium-catalyzed
carbonylation of aryl iodides. The combination of sterically encumbered
phosphines (PtBu3) and CO coordination
has been found to facilitate the rapid carbonylation of aryl iodides
into acid chlorides via reductive elimination from (tBu3P)(CO)Pd(COAr)Cl. The formation of acid chlorides
can also be exploited to perform traditional aminocarbonylation reactions
under exceptionally mild conditions (ambient temperature and pressure),
and with a range of weakly nucleophilic substrates.
创建时间：
2013-11-13
