Logistic regression of low ranked cognitive function (lowest quintile) in midlife (~50 y) on inflammatory markers at age ~30 y (baseline) or ~43 y (follow-up) and 13 y change in GlycA: the Jerusalem LRC longitudinal study.

LRC, Lipid Research Clinic; CRP, C-reactive protein.a Box-Cox transformed CRP (λ = 0).b Additionally adjusted for baseline measurement of GlycA and time elapsed between measurements.c Compared to the 4 lowest quintiles grouped.Model 1: UnadjustedModel 2: Adjusted for age, sex, educational level, origin, childhood SES (ICBS ranking) and adult SES (ICBS ranking), depression, and baseline leisure-time vigorous activity, smoking status and BMI measured at ages 28–32.Model 3: Model 2 plus change in smoking status, change in BMI, and duration between measurements. Reference level of dummy variables: sex, females; educational level, elementary (d Missing data: CRP (n = 14), white blood cell count (n = 12), fibrinogen (n = 43), GlycA at baseline (n = 21), GlycA change (n = 23), adult SES (n = 5), depression (n = 4), leisure-time vigorous activity (n = 1), change in BMI (n = 1). Missing values of adult SES, depression, leisure-time vigorous activity and change in BMI were replaced with non-missing median or mean values.P-values in parentheses.* p ** p Logistic regression of low ranked cognitive function (lowest quintile) in midlife (~50 y) on inflammatory markers at age ~30 y (baseline) or ~43 y (follow-up) and 13 y change in GlycA: the Jerusalem LRC longitudinal study.