Dynamic Kinetic Resolution for Construction of Three Transannular Stereocenters of Dihydrobenzofuranols
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A handy and effective method was established to obtain the cis-2,3-dihydrobenzofuranols having three stereocenters, involving asymmetric transfer hydrogenation of benzofuranones via dynamic kinetic resolution. The general applicability of this method was examined with different benzofuran-3-(2H)-ones, and stereoselectivities of 85–99% ee and up to 98/2 dr were obtained.
创建时间:
2018-09-26



