Formal Synthesis of (±)-Methyl Rocaglate Using an Unprecedented Acetyl Bromide Mediated Nazarov Reaction

To date the prototype Nazarov cyclization of a cross-conjugated
pentadienone to the core structure of the rocaglate natural products
has not been successful (9 into 12). It
has been found that this conversion can be achieved by the use of
acetylbromide in excellent yield and results in a strategically very
direct route to these antitumor agents.

迄今为止，原型纳扎罗夫环化反应将跨共轭戊二烯酮转化为罗卡格莱特天然产物核心结构的尝试尚未取得成功（9至12位）。研究发现，通过使用乙酰溴化物，可以实现这一转化，并以极高的产率获得理想的结果，从而为这些抗癌剂提供了一种战略上极为直接的合成途径。