Global knock out of Sirt3 gene in Alzheimer’s transgenic mice with amyloid pathology. Global knock out of Sirt3 gene in Alzheimer’s transgenic mice with amyloid pathology

We have previously demonstrated that Sirt3 gene deletion, a model for metabolic syndrome, leads to brain mitochondrial dysfunction and neuroinflammation. We also reported that silencing of Sirt3 gene in APP/PS1 mice results in exacerbation of insulin resistance, neuroinflammation and β amyloid plaque deposition. To further understand how metabolic syndrome and amyloid pathology interact, we performed RNA-seq analysis of the brain samples from wild type, Sirt3-/- , APP/PS1 and APP/PS1/Sirt3-/- mice. Overall design: Comparative gene expression profiling analysis of RNA-seq data from the brain of C57/BL6 (WT), Sirt3-/- (S3), APP/PS1 (AP) and APP/PS1/Sirt3-/- (AP_S3) mice