RNA-seq analysis of DLBCL cell lines in response to chemotherapy

Despite the long-standing role of standard chemotherapy in human diffuse large B cell lymphoma (DLBCL), the basis for individual tumor responses and how they associate with different transcriptional programs are incompletely understood. Hence we aimed to classify DLBCL cell lines by their ability to undergo therapy-induced senescence (TIS) in response to adriamycin (aka doxorubicin) and acquire gene expression profiles before and after chemotherapy by RNA-seq. Overall design: Comparative gene expression profiling analysis of RNA-seq data for DLBCL cell lines categroized by their ability to senescence in response to adriamycin treatment.