Effects of CDK8/19 mediator kinase inhibition by Senexin B in HAP-1 cells treated with or without interferon-gamma

RNA-Seq analysis was carried out to investigate the effects of selective CDK8/19 inhibitor Senexin B on gene transcription mediated by IFN-gamma signaling pathway in HAP-1 cells. Overall design: HAP-1 cells were pre-treated with or without 1 µM Senexin B for 1 hour, followed by treatment with or without 10ng/mL IFN-gamma for 4 hours. Each treatment condition was done in biological triplicate.