Lipe KO line genotyping

NIAID Data Ecosystem2026-05-01 收录

基因敲除模型

视网膜病变机制

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA956881 数据链接链接失效反馈

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资源简介：

Here, we genotyped the Lipe-/- mice generated using CRISPR-Cas9 technology and found to develop accumulation of subretinal microglia, a retinal degeneration with decreased visual function, an abnormal retinal lipid profile.

创建时间：

2023-04-18

Gene expression data from the skin of Cdsniep-/-adult mice. Mus musculus

疾病分子机制

基因敲除模型

Peeling Skin Disease (PSD; OMIM 270300) is an inflammatory ichthyosis due to homozygous loss-of-function mutations in Corneodesmosin (CDSN) and characterized by lifelong patchy peeling of the skin ass

NIAID Data Ecosystem60

Transcriptome profiling of murine aortic Vascular Smooth Muscle cells from ApoE knockout and ApoE/Neil3 double knockout mice. Transcriptome profiling of murine aortic Vascular Smooth Muscle cells from ApoE knockout and ApoE/Neil3 double knockout mice

平滑肌细胞转录调控

基因敲除模型

We performed high-throughput RNA sequencing to characterize possible differences in the transcriptome of murine aortic Vascular Smooth Muscle cells from both 26 weeks-old ApoE knockout and ApoE/Neil3

NIAID Data Ecosystem50

Serum levels of PGE 2 in wild-type and IVA-PLA 2 -knockout mice.

脂代谢炎症研究

基因敲除模型

Wild-type and IVA-PLA2-knockout (KO) mice were fed normal (N) or high-fat (HF) diets for 16 weeks and fasted. The serum levels of PGE2 were measured (n = 3–5). aP<0.05 versus wild-type mice fed normal

NIAID Data Ecosystem40

Table1_Retinal Development and Pathophysiology in Kcnj13 Knockout Mice.xlsx

视网膜病变机制

基因治疗模型开发

Purpose: We constructed and characterized knockout and conditional knockout mice for KCNJ13, encoding the inwardly rectifying K+ channel of the Kir superfamily Kir7.1, mutations in which cause both Sn

NIAID Data Ecosystem50

DIA quantification proteomics to compare protein expression differences in the hippocampus of wild-type and Mdga2 +/− mice.

神经细胞蛋白质组学

基因敲除模型

DIA quantification proteomics to compare protein expression differences in the hippocampus of wild-type and Mdga2 +/− mice.

Figshare2025-04-01 更新40