Top Activated Upstream Regulators¹.

1Top upstream regulators selected based on p value of overlap and activation Z score. Data are ordered by p value of overlap. If more than 10 pathways were indicated as activated for a condition, the top 10 regulators were chosen as the 10 most significant regulators (based on p value) that had a Z score ≥ 2. 2Z score infers the activation states of predicted regulators based on expression of the downstream genes within the pathway; a score ≥ 2 indicates activation. 3P value of overlap evaluates whether there is a statistically significant overlap between differentially expressed genes and the genes that are regulated by the upstream regulator. Top Activated Upstream Regulators1.