Summary of genes and genetic interactions regulating SC endoreplication and growth.

Table summarises the different genetic manipulations used in this study, the signalling pathway or gene that is tested by these manipulations, and the effects on SC endoreplication and nuclear growth (used as a proxy for SC growth) in virgin and mated males. Note that since endoreplication does not normally occur in virgin males, manipulations, which reduce endoreplication, will have no effect in virgins. In some genetic backgrounds, mating males no longer affects SC growth relative to virgin males (marked ‘No’), unlike in control males and other backgrounds, where SCs from multiply mated males grow more than SCs from virgins (marked ‘Yes’). On the right hand side, a summary of the epistatic interactions between different genes is provided. Note that the BMP signalling pathway affects endoreplication-dependent and endoreplication-independent growth via different routes (E2F1-dependent and -independent respectively), and that it remains unclear whether CycE mediates all the mating-dependent effects of the EcR on endoreplication and growth (see Fig 6H). (XLSX)