APS1 and celiac patients reveal autoimmune amelogenesis imperfecta

To investigate the dependence of amelogenesis imperfecta-related gene expression and ameloblast-related gene expression on Aire in the thymus, mTEChi from Aire+/+ and Aire-/- were sorted and subjected to bulk RNAseq. Overall design: mRNA profiles of mature medullary thymic epithelial cells (mTEChi) from young (4.5 weeks old) NOD.Aire-/- mice ,were generated by deep sequencing, using the MARSseq method.